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:: Volume 5, Issue 5 (November-December 2017) ::
IJPN 2017, 5(5): 43-48 Back to browse issues page
Identification of Some Risk Factors of Recurrent Relapses Interval Duration in Patients with Schizoaffective Disorder
Robab Zareie Shabkhaneh * , Mohammad Reza Khodaei Ardakani , Masoud Karimlou , Mahdi Rahgozar
Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran , m_rahgozar2003@yahoo.com.au
Abstract:   (4709 Views)
Introduction: Identifying risk factors of recurrent relapses interval durations in patients with schizoaffective disorder in order to increase the intervals of relapses is important. Controlling the disorder procedure in this recursive disorder is one of the treatment stages. This study aimed to identify some risk factors of recurrent relapses intervals in patients with schizoaffective disorder.
Methods: Medical records of 212 treated patients with schizoaffective disorder in Tehran Razi Mental Center were investigated. In addition to the recurrent relapses and hospital discharge times, factors including gender, marital status, education, and history of substance abuse, alcohol and psychedelic pills usage were also investigated as possible influential factors in the process. Gap time recurrent frailty model of survival analysis was fitted to the data and model parameters were estimated using EM algorithm with R3.2.1 software.
Results: Of the patients, 74.5%, 33% and 67% were male, single and with history of smoking, respectively. Frailty parameter was significant (θ ̂ = 0.232, P = 0.021). Gender (P < 0.001), marital status (P = 0.017), education (P < 0.001), occupation (P = 0.035) and history of drug abuse (P = 0.041) were the factors identified as significant risk factors of recurrent relapse intervals. The frailty variance (θ ̂  = 0.232, P = 0.021) indicated wide individual variations in characters, which were significant.
Conclusions: Significance of the frailty parameter indicated that the impact of entered individual factors on relapse intervals in patient with schizoaffective disorder was unmeasurable. Male patients indicated 0.78 times more than females, illiterates 0.9 times less than those with diplomas, singles 0.83 times more than married people, psychotropic pills consumers 0.91 times and alcohol consumers 0.83 times more than others, and self-employed people, housewives and unemployed ones experienced subsequent relapses 0.85, 0.81 and 0.83 times faster.
 
Keywords: Schizoaffective Disorder, Delayed Relapses, Recurrent Gap-Time Model with Frailty, Survival Analysis
Full-Text [PDF 85 kb]   (1365 Downloads)    
Type of Study: Applicable | Subject: General
Received: 2017/08/18 | Accepted: 2017/12/24 | Published: 2017/12/24 | ePublished: 2017/12/24
References
1. 1. Kaplan HI, Sadock BJ. Synopsis of psychiatry: Behavioral sciences clinical psychiatry. Clin Psychiat. 1988;9(1):63-90.
2. 2. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261-76. [DOI:10.1093/schbul/13.2.261] [PMID]
3. 3. Kane JM. Schizophrenia. N Engl J Med. 1996;334(1):34-41. [DOI:10.1056/NEJM199601043340109] [PMID]
4. 4. Perkins DO, Gu H, Weiden PJ, McEvoy JP, Hamer RM, Lieberman JA, et al. Predictors of treatment discontinuation and medication nonadherence in patients recovering from a first episode of schizophrenia, schizophreniform disorder, or schizoaffective disorder: a randomized, double-blind, flexible-dose, multicenter study. J Clin Psychiatry. 2008;69(1):106-13. [DOI:10.4088/JCP.v69n0114] [PMID]
5. 5. Remington G. Antipsychotic dosing: still a work in progress. Am J Psychiatry. 2010;167(6):623-5. [DOI:10.1176/appi.ajp.2010.10030302] [PMID]
6. 6. Woods SW. Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry. 2003;64(6):663-7. [DOI:10.4088/JCP.v64n0607] [PMID]
7. 7. Grace AA. Dopamine system dysregulation by the hippocampus: implications for the pathophysiology and treatment of schizophrenia. Neuropharmacology. 2012;62(3):1342-8. [DOI:10.1016/j.neuropharm.2011.05.011] [PMID] [PMCID]
8. 8. Kelly PJ, Lim LL. Survival analysis for recurrent event data: an application to childhood infectious diseases. Stat Med. 2000;19(1):13-33. https://doi.org/10.1002/(SICI)1097-0258(20000115)19:1<13::AID-SIM279>3.0.CO;2-5 [DOI:10.1002/(SICI)1097-0258(20000115)19:13.0.CO;2-5]
9. 9. Gohari MR. [Fraility models for recurrent events with short term dependence]. Tehran Tehran University of Medical Sciences; 2005. [PMID]
10. 10. Masyn KE. Discrete-time survival mixture analysis for single and recurrent events using latent variables. Los Angeles, California: University of California; 2003.
11. 11. Kleinbaum D, Klein M. Survival analysis: Springer; 1996. [DOI:10.1007/978-1-4757-2555-1] [PMID]
12. 12. Lee A, Zhao Y, Yau K, Ng S, editors. Survival mixture modelling of recurrent infections. IASC2008; 2008; Japan: Japanese Society of Computational Statistics.
13. 13. Smith TE, Hull JW, Goodman M, Hedayat-Harris A, Willson DF, Israel LM, et al. The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder. J Nerv Ment Dis. 1999;187(2):102-8. [DOI:10.1097/00005053-199902000-00006] [PMID]
14. 14. Brown ES, Jeffress J, Liggin JD, Garza M, Beard L. Switching outpatients with bipolar or schizoaffective disorders and substance abuse from their current antipsychotic to aripiprazole. J Clin Psychiatry. 2005;66(6):756-60. [DOI:10.4088/JCP.v66n0613] [PMID]
15. 15. Mueser KT, Yarnold PR, Bellack AS. Diagnostic and demographic correlates of substance abuse in schizophrenia and major affective disorder. Acta Psychiatr Scand. 1992;85(1):48-55. [DOI:10.1111/j.1600-0447.1992.tb01441.x] [PMID]
16. 16. Tondo L, Vazquez GH, Baethge C, Baronessa C, Bolzani L, Koukopoulos A, et al. Comparison of psychotic bipolar disorder, schizoaffective disorder, and schizophrenia: an international, multisite study. Acta Psychiatr Scand. 2016;133(1):34-43. [DOI:10.1111/acps.12447] [PMID]
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Zareie Shabkhaneh R, Khodaei Ardakani M R, Karimlou M, Rahgozar M. Identification of Some Risk Factors of Recurrent Relapses Interval Duration in Patients with Schizoaffective Disorder. IJPN 2017; 5 (5) :43-48
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Volume 5, Issue 5 (November-December 2017) Back to browse issues page
نشریه روان پرستاری Iranian Journal of  Psychiatric Nursing
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