Introduction: Infertility in women is a stressful experience and critical period. By losing the chance of pregnancy, women's levels of psychological distress, and anguish increases and their psychological well-being decreases. Perceived social support for women can be affected and change by infertility. The purpose of this research was to compare perceived social support and psychological well-being between pregnant women with surrogacy, assisted reproductive Technology(ART) and natural fertility in Isfahan.

Methods: The method of this research was ex post facto. Therefore 90 pregnant women  with surrogacy, with ART were selected among referral women  to Isfahan infertility clinics and  pregnant women with natural Fertility were selected among the referral women  to fertility clinic by Convenience sampling. These women responded to Mitchell and Zimeth's (2000) perceived social support scale and Ryff (1989) psychological well-being.

Results: The results of MANOVA showed that there is a significant difference between methods of fertility in Perceived social support (important person and family) (p<0.001), and pregnant women  with ART had more perceived social support compared to  pregnant women with natural fertility. In addition, surrogate women compared to the other two groups had lower perceived social support. Also there is a significant difference in psychological well-being subscales of positive relations, environmental mastery, personal growth, purposeful (p <0.001) and self-acceptance (p <0.05) and  the mean of psychological well-being in pregnant women with natural fertility was higher than two other groups  .

Conclusion: These results have important implications about these structures and importance of psychological interventions for fertile women with different ways.